Cannabis Research - Appetite Stimulation
- Dronabinol and Marijuana in HIV-Positive Marijuana Smokers - Caloric Intake, Mood, and Sleep
Objectives: Individuals with HIV constitute the largest group
using cannabinoids for medicinal reasons; yet, no studies have
directly compared the tolerability and efficacy of smoked marijuana
and oral dronabinol maintenance in HIV-positive marijuana smokers.
This placebo-controlled within-subjects study evaluated marijuana
and dronabinol across a range of behaviors: eating topography, mood,
cognitive performance, physiologic measures, and sleep.
Conclusions: These data suggest that for HIV-positive marijuana
smokers, both dronabinol (at doses 8 times current recommendations)
and marijuana were well tolerated and produced substantial and
comparable increases in food intake.
Cannabis Hope for Inflammatory Bowel Disease
ScienceDaily (Dec. 21, 2009) " Chemicals found in cannabis could prove an
effective treatment for the inflammatory bowel diseases Ulcerative Colitis
and Crohn's Disease, say scientists.
Laboratory tests have shown that two compounds found in the cannabis plant
-- the cannabinoids THC and cannabidiol -- interact with the body's system
that controls gut function.
Crohn's Disease and Ulcerative Colitis, which affect about one in every 250
people in Northern Europe, are caused by both genetic and environmental
factors. The researchers believe that a genetic susceptibility coupled with
other triggers, such as diet, stress or bacterial imbalance, leads to a
defective immune response.
Dr Karen Wright, Peel Trust Lecturer in Biomedicine at Lancaster University,
presented her soon-to-be published work at The British Pharmacological
Society's Winter Meeting in London.
She said: "The lining of the intestines provides a barrier against the
contents of the gut but in people with Crohn's Disease this barrier leaks
and bacteria can escape into the intestinal tissue leading to an
inappropriate immune response.
"If we could find a way to restore barrier integrity in patients we may be
able to curb the inflammatory immune response that causes these chronic
Dr Wright, working with colleagues at the School of Graduate Entry Medicine
and Health in Derby, has shown that cells that react to cannabinoid
compounds play an important role in normal gut function as well as the
immune system's inflammatory response.
"The body produces its own cannabinoid molecules, called endocannabinoids,
which we have shown increase the permeability of the epithelium during
inflammation, implying that overproduction may be detrimental," said Dr
"However, we were able to reverse this process using plant-derived
cannabinoids, which appeared to allow the epithelial cells to form tighter
bonds with each other and restore the membrane barrier."
The research was carried out using cell cultures in a dish but,
interestingly, when the team attempted to mimic the conditions of the gut by
reducing the amount of oxygen in the cells' environment, much lower
concentrations of cannabinoid were needed to produce the same effect.
Dr Wright added: "What is also encouraging is that while THC has
psychoactive properties and is responsible for the 'high' people experience
when using cannabis, cannabidiol, which has also proved effective in
restoring membrane integrity, does not possess such properties."
Adapted from materials provided by British Pharmacological Society, via
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APA - British Pharmacological Society (2009, December 21). Cannabis hope for
inflammatory bowel disease. ScienceDaily. Retrieved December 21, 2009, from
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Disease." ScienceDaily 21 December 2009. 21 December 2009 .
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